Ocular involvement in paediatric haemolytic uraemic syndrome

Cutaneous involvement in haemolytic uraemic syndrome

A 35-year-old woman was admitted to our hospital with severe hypertension, oedema and renal failure. Twelve months earlier, she had a pregnancy, which was complicated by preeclampsia. A successful Caesarean was performed in the 29th week of gestation (Figures 1 and 2). After the birth, she remained with poorly controlled hypertension and proteinuria exceeding 1 g/day. Six months later, she bega...

Atypical haemolytic-uraemic syndrome in a young patient with renal, neurological, ocular and cardiovascular involvement.

Immunoadsorption for paediatric post-diarrhoea haemolytic-uraemic syndrome with severe neurological involvement

The haemolytic-uraemic syndrome (HUS), a thrombotic microangiopathy, occurs often secondary to an infection due to Shiga-toxin-producing Escherichia coli (E Coli), the most threatening complication being neurological involvement [1]. Plasmata exchange has been shown to have some efficiency [2, 3]. Use of complement cascade-blocking antibody eculizumab is becoming the first-line treatment in the...

Atypical haemolytic uraemic syndrome.

The haemolytic uraemic syndrome (HUS) is characterized by the triad of thrombocytopenia, microangiopathic haemolytic anaemia and acute renal failure. HUS may be classified as either diarrhoeal-associated or non-diarrhoeal/atypical (aHUS). aHUS has recently been shown to be a disease of complement dysregulation, with 50% of cases involving the complement regulatory genes, factor H (CFH), membran...

Haemolytic uraemic syndrome

Haemolytic uraemic syndrome and the related disorder thrombotic thrombocytopenic purpura have recently been the subject of much interest and research.' A wide variety of phenomena have been observed and several pathogenetic mechanisms have been proposed, matched by a correspondingly diverse array of promising but unsubstantiated methods of treatment. Consideration of the heterogeneity of the cl...